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Within an interacting comments loop, CLOCK-BMAL1 complexes activate expression of nuclear receptors, REV-ERB α and RORα. Their protein goods opinions to regulate BMAL1 by competitively binding retinoic acid-related orphan receptor response factors within the BMAL1 promoter40. REV-ERBs repress the transcription of BMAL1, While RORs activate it. Bo
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